Google Scholar. Significance of apparent diffusion coefficient measurement for the differential diagnosis of multiple system atrophy, progressive supranuclear palsy, and Parkinson's disease: evaluation by 3. Neurobiol Aging. Individual detection of patients with Parkinson disease using support vector machine analysis of diffusion tensor imaging data: initial results.
A decision tree for differentiating multiple system atrophy from Parkinson's disease using 3-T MR imaging. Imaging measures predict progression in progressive supranuclear palsy. In vivo evaluation of white matter pathology in patients of progressive supranuclear palsy using TBSS. Disrupted cerebellar connectivity reduces whole-brain network efficiency in multiple system atrophy.
Diffusion tensor imaging in Parkinsonian syndromes: a systematic review and meta-analysis. This systematic review and meta-analysis describes many of the important diffusion MRI studies that predated those described in Table 1 and describes a significant effect size for decreased FA in the SN in PD patients compared with controls.
Sherer TB. Biomarkers for Parkinson's disease. Sci Transl Med. Connectivity-based segmentation of the substantia nigra in human and its implications in Parkinson's disease. High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease. Effects of aging on the ventral and dorsal substantia nigra using diffusion tensor imaging.
Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson's disease. Neurobiol Dis. J Park Dis. Midbrain iron content in early Parkinson disease: a potential biomarker of disease status. Further, the two measures were not correlated, suggesting they might represent different pathological processes in PD. Principles and practice of movement disorders.
Edinburgh: Saunders; Anatomical correlates of blepharospasm. Transl Neurodegener. White matter abnormalities in gene-positive myoclonus-dystonia.
Blood AJ. We are delighted to report that our study is making very good progress and is also leading to a number of interesting developments. Amazon Advertising Find, attract, and engage customers. Charles Watson. This review describes current thinking regarding the neuroanatomic substrates of dystonia, and provides as a critical appraisal of the evidence from pathology, imaging including diffusion MRI , and physiologic studies.
The structural correlates of functional deficits in early Huntington's disease. Multimodal MRI analysis of the corpus callosum reveals white matter differences in presymptomatic and early Huntington's disease. Cereb Cortex. A complementary diffusion tensor imaging DTI -histological study in a model of Huntington's disease. Early changes in white matter pathways of the sensorimotor cortex in premanifest Huntington's disease. Automated differentiation of pre-diagnosis Huntington's disease from healthy control individuals based on quadratic discriminant analysis of the basal ganglia: the IMAGE-HD study.
Diffusion weighted imaging of prefrontal cortex in prodromal Huntington's disease. Mapping cortico-striatal connectivity onto the cortical surface: a new tractography-based approach to study Huntington disease. Decreased cerebellar fiber density in cortical myoclonic tremor but not in essential tremor.
The functional neuroanatomy of dystonia. This review describes current thinking regarding the neuroanatomic substrates of dystonia, and provides as a critical appraisal of the evidence from pathology, imaging including diffusion MRI , and physiologic studies. Structural, functional and molecular imaging of the brain in primary focal dystonia—a review. This extensive review focuses on the role of neuroimaging specifically in focal dystonia, and includes descriptions of many of the important studies published prior to those listed in Table 2. Hereditary dystonia as a neurodevelopmental circuit disorder: evidence from neuroimaging.
Microstructural white matter changes in carriers of the DYT1 gene mutation. Ann Neurol. Microstructural white matter changes in primary torsion dystonia. Cerebellothalamocortical pathway abnormalities in torsinA DYT1 knock-in mice. This animal model of dystonia study is important because it demonstrated cerebellothalamic diffusion MRI changes in mutants compared with controls that correlated with measures of cortical metabolic activity, somewhat similar to the findings of Argyelan et al.
Diffusion tensor imaging in primary cervical dystonia. J Neurol Neurosurg Psychiatry.
Diffusion tensor imaging in patients with primary cervical dystonia and in patients with blepharospasm. Eur J Neurol. Structural white matter abnormalities in patients with idiopathic dystonia. Disrupted thalamic prefrontal pathways in patients with idiopathic dystonia.
Diffusion abnormalities in the primary sensorimotor pathways in writer's cramp. Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study. Blood AJ. New hypotheses about postural control support the notion that all dystonias are manifestations of excessive brain postural function.
Biosci Hypotheses. White matter abnormalities in dystonia normalize after botulinum toxin treatment. Structural MRI in Huntington's disease and recommendations for its potential use in clinical trials. Neurosci Biobehav Rev.
Detection of Huntington's disease decades before diagnosis: the Predict-HD study. Lancet Neurol. Magnetic resonance imaging of Huntington's disease: preparing for clinical trials. Huntington disease: volumetric, diffusion-weighted, and magnetization transfer MR imaging of brain.
Regional white matter change in pre-symptomatic Huntington's disease: a diffusion tensor imaging study. Psychiatry Res. Diffusion tensor imaging in presymptomatic and early Huntington's disease: selective white matter pathology and its relationship to clinical measures. Diffusion-weighted imaging in Huntington's disease. Diffusion tensor imaging in preclinical Huntington's disease. Brain Imaging Behav. Contrasting gray and white matter changes in preclinical Huntington disease: an MRI study. Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection".
Stability of white matter changes related to Huntington's disease in the presence of imaging noise: a DTI study. PLoS Curr. Diffusion tensor imaging in Huntington's disease reveals distinct patterns of white matter degeneration associated with motor and cognitive deficits. Seeking brain biomarkers for preventive therapy in Huntington disease. CNS Neurosci Ther. This review highlights the neuroimaging literature including diffusion MRI and details the findings of previous studies aimed at developing imaging-based potential biomarkers for HD, and includes an interesting figure highlighting potential biomarkers according to each period of disease progression.
Longitudinal diffusion tensor imaging in Huntington's disease. Exp Neurol. A longitudinal diffusion tensor imaging study in symptomatic Huntington's disease. Regional distribution and clinical correlates of white matter structural damage in Huntington disease: a tract-based spatial statistics study. White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington's disease. The kynurenine pathway in neurodegenerative diseases: mechanistic and therapeutic considerations.
J Neurol Sci. Genotype specific age related changes in a transgenic rat model of Huntington's disease.